Axitinib (By mouth)
Treats kidney cancer.
InlytaThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to axitinib, or if you are pregnant.
How to Use This Medicine:
- Take your medicine as directed. Your dose may need to be changed several times to find what works best for you. Take each dose about 12 hours apart.
- Swallow the tablet whole with a glass of water. Do not break, crush, or chew it.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor for instructions.
- If you vomit after you take the medicine, do not take an additional dose. Take your next dose at the regular time.
- Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some foods and medicines can affect how axitinib works. Tell your doctor if you are using any of the following:
- Bosentan, dexamethasone, modafinil, nafcillin, nefazodone, St John's wort
- Medicine to treat an infection (including clarithromycin, itraconazole, ketoconazole, rifabutin, rifampin, rifapentine, telithromycin, voriconazole)
- Medicine to treat HIV/AIDS (including atazanavir, efavirenz, etravirine, indinavir, nelfinavir, ritonavir, saquinavir)
- Medicine to treat seizures (including carbamazepine, phenobarbital, phenytoin)
- Do not eat grapefruit or drink grapefruit juice while you are using this medicine.
Warnings While Using This Medicine:
- This medicine may cause birth defects if either partner is using it during conception or pregnancy. Tell your doctor right away if you or your partner becomes pregnant. Use an effective form of birth control during treatment with this medicine and for 1 week after the last dose. Male patients with female partners should use an effective form of birth control during treatment and for 1 week after the last dose.
- Do not breastfeed during treatment and for 2 weeks after the last dose.
- Tell your doctor if you have liver disease, high blood pressure, thyroid problems, stomach or bowel bleeding, or a history of heart attack, heart failure, stroke, or blood clotting problems.
- This medicine may cause the following problems:
- High blood pressure
- Bleeding problems or blood clots
- Heart failure
- Stomach or bowel problems (including perforation, fistula)
- Thyroid problems
- Reversible posterior leukoencephalopathy syndrome (RPLS)
- Liver problems
- Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
- Cancer medicine can cause nausea or vomiting, sometimes even after you receive medicine to prevent these effects. Ask your doctor or nurse about other ways to control any nausea or vomiting that might happen.
- Tell any doctor or dentist who treats you that you are using this medicine. You may need to stop using this medicine several days before you have surgery or medical tests. Do not use this medicine for at least 24 hours before a scheduled surgery.
- This medicine could cause infertility. Talk with your doctor before using this medicine if you plan to have children.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Chest pain, trouble breathing, coughing up blood
- Dark urine or pale stools, nausea, vomiting, loss of appetite, stomach pain, yellow skin or eyes, cloudy urine
- Fast, slow, or pounding heartbeat
- Numbness or weakness on one side of your body, sudden or severe headache, pain in your calf, problems with vision, speech, or walking
- Red or brown urine, bloody or black stools, vomiting blood
- Redness, pain, swelling, or blisters on the palms of your hands or soles of your feet
- Seizure, headache, confusion, trouble seeing
- Severe or ongoing stomach pain
- Swelling in your hands, ankles, or feet
- Tiredness, feeling too hot or cold, hair loss, weight gain, or voice changes
- Unusual bleeding, bruising, tiredness, or weakness
If you notice these less serious side effects, talk with your doctor:
- Decreased appetite, weight loss
- Diarrhea, constipation
- Joint or muscle pain
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 10/10/2019
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