Dexrazoxane (By injection)
Helps prevent heart problems in women receiving doxorubicin for breast cancer. Also treats tissue damage caused by cancer medicines leaking from the blood vessels.
Totect, ZinecardThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. You should not receive it if you are pregnant.
How to Use This Medicine:
- Your doctor will prescribe your dose and schedule. This medicine is given through a needle placed in a vein. It must be given slowly, so the needle will have to stay in place for at least 1 hour.
- You will receive this medicine while you are in a hospital or cancer treatment center. A nurse or other trained health professional will give you this medicine.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: This medicine needs to be given on a fixed schedule. If you miss a dose, call your doctor, home health caregiver, or treatment clinic for instructions.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines may affect how dexrazoxane works. Tell your doctor if you are also using topical dimethylsulfoxide (DMSO).
Warnings While Using This Medicine:
- It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Tell your doctor right away if you become pregnant.
- Tell your doctor if you are breastfeeding, or if you have liver disease, kidney disease, or a blood disorder.
- This medicine can increase your risk for certain cancers, including leukemia. Talk to your doctor if you have questions or concerns.
- This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- If you are also taking doxorubicin: This medicine may not protect your heart completely. It is important to tell your doctor if you have any symptoms of heart problems, including trouble breathing, chest pain, lightheadedness, dizziness, or a fast or uneven heartbeat.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Fever, chills, cough, sore throat, body aches
- Unusual bleeding, bruising, or weakness
If you notice these less serious side effects, talk with your doctor:
- Nausea, vomiting
- Pain, burning, redness, or swelling under your skin where the needle is placed
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 3/4/2018
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