Insulin lispro protamine/insulin lispro (By injection)
Insulin Lispro Protamine, Recombinant (IN-su-lin LIS-pro PROE-ta-meen, ree-KOM-bi-nant), Insulin Lispro, Recombinant (IN-su-lin LIS-pro, ree-KOM-bi-nant)
HumaLOG Mix 50/50, HumaLOG Mix 50/50 KwikPen, HumaLOG Mix 75/25, HumaLOG Mix 75/25 KwikPenThere may be other brand names for this medicine.
When This Medicine Should Not Be Used:
This medicine is not right for everyone. Do not use it if you had an allergic reaction to insulin lispro.
How to Use This Medicine:
- Your doctor will prescribe your exact dose and tell you how often it should be given. This medicine is given as a shot under your skin.
- Your healthcare provider will work with you to personalize your dose and treatment based on your insulin needs and lifestyle. You will be taught how to give yourself the injections. Make sure you understand all instructions. Ask your doctor if you have questions.
- Always double-check both the concentration (strength) of your insulin and your dose. Concentration and dose are not the same. The dose is how many units of insulin you will use. The concentration tells how many units of insulin are in each milliliter (mL), such as 100 units/mL (U-100), but this does not mean you will use 100 units at a time.
- Inject this medicine 15 minutes before a meal (2 meals or a meal and a snack).
- You will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas.
- Use a new needle and syringe each time you inject your medicine. If you use a syringe, use only the kind that is made for insulin injections. Some insulins must be given with a specific type of syringe or needle. Ask your pharmacist if you are not sure which one to use.
- Vial: Invert the vial carefully at least 10 times to mix the insulin.
- Pen: Mix the insulin by rolling the pen between your palms 10 times. Turn the pen upside down at least 10 times.
- Do not mix this insulin with any other insulin.
- The insulin should look cloudy or milky white after you mix it. Do not use this insulin if it is clear or has clumps or particles in it.
- Do not store the pen with a needle attached.
- Always check the label before use, to make sure you have the correct type of insulin. Do not change the brand, type, or concentration unless your doctor tells you to. Do not use a an infusion pump or other device to use this medicine.
- Keep all medicine away from heat and direct light.
- Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.
- Missed dose: Call your doctor or pharmacist for instructions.
- Unopened medicine: Keep the medicine in its original carton. You may store the pen or vial in the refrigerator until its expiry date. Do not freeze. Do not use the insulin if it has been frozen. You may also store the pen for 10 days or vial for 28 days at room temperature.
- Opened medicine:
- Pen: Store at room temperature for up to 10 days. Do not refrigerate.
- Vials: Store in the refrigerator or at room temperature for up to 28 days. Do not freeze.
- Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.
Drugs and Foods to Avoid:
Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.
- Some medicines can change the amount of insulin you need to use and make it harder for you to control your diabetes. Tell your doctor about all other medicines that you are using.
- Limit how much alcohol you drink.
Warnings While Using This Medicine:
- Tell your doctor if you are pregnant or breastfeeding, or if you have kidney disease, liver disease, heart disease, or heart failure.
- This medicine may cause the following problems:
- Low blood sugar or low potassium levels in the blood
- Fluid retention or heart failure (when used together with a thiazolidinedione [TZD] medicine)
- Never share insulin pens or needles with anyone. Sharing these can pass hepatitis viruses, HIV, or other illnesses from one person to another.
- Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.
- Keep all medicine out of the reach of children. Never share your medicine with anyone.
Possible Side Effects While Using This Medicine:
Call your doctor right away if you notice any of these side effects:
- Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
- Dry mouth, increased thirst, muscle cramps, nausea, vomiting, uneven heartbeat
- Rapid weight gain, swelling in your hands, ankles, or feet, chest pain, trouble breathing, tiredness
- Shaking, trembling, sweating, fast or pounding heartbeat, lightheadedness, hunger, confusion
If you notice these less serious side effects, talk with your doctor:
- Redness, itching, swelling, or skin changes where the shot is given
If you notice other side effects that you think are caused by this medicine, tell your doctor
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088
Last Updated: 10/10/2019
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