Peptic ulcer - gastrin blood test
The gastrin blood test measures the amount of the hormone gastrin in blood.
How to Prepare for the Test
Certain medicines may affect the results of this test. Your health care provider will tell you if you need to stop taking any medicines. Do NOT stop taking any medicine before talking to your provider.
Medicines that can increase gastrin level include stomach acid reducers, such as antacids, H2 blockers (ranitidine and cimetidine), and proton pump inhibitors (omeprazole and pantoprazole).
Drugs that can decrease gastrin level include caffeine, corticosteroids, and the blood pressure drugs deserpidine, reserpine, and rescinnamine.
How the Test will Feel
When the needle is inserted to draw blood, some people feel moderate pain. Others feel only a prick or stinging sensation. Afterward, there may be some throbbing or a slight bruise. This soon goes away.
Why the Test is Performed
Gastrin is the main hormone that controls the release of acid in your stomach. When there is food in the stomach, gastrin is released into the blood. As the acid level rises in your stomach and intestines, your body normally makes less gastrin.
Your provider may order this test if you have signs or symptoms of a problem linked to an abnormal amount of gastrin. This includes peptic ulcer disease.
Normal values are generally less than 100 pg/mL (48.1 pmol/L).
Normal value ranges may vary slightly among different laboratories. Some labs use different measurements or test different samples. Talk to your provider about the meaning of your specific test result.
What Abnormal Results Mean
Too much gastrin can causes severe peptic ulcer disease. A higher than normal level may also be due to:
- Chronic kidney disease
- Long-term gastritis
- Over-activity of the gastrin-producing cells in the stomach (G-cell hyperplasia)
- Helicobacter pylori infection of the stomach
- Use of antacids or medicines to treat heartburn
- Zollinger-Ellison syndrome, a gastrin-producing tumor that may develop in the stomach or pancreas
- Decreased acid production in the stomach
- Previous stomach surgery
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Chernecky CC, Berger BJ. Gastrin - serum. In: Chernecky CC, Berger BJ, eds. Laboratory Tests and Diagnostic Procedures. 6th ed. St Louis, MO: Elsevier Saunders; 2013:571-572.
Siddiqi HA, Salwen MJ, Shaikh MF, Bowne WB. Laboratory diagnosis of gastrointestinal and pancreatic disorders. In: McPherson RA, Pincus MR, eds. Henry's Clinical Diagnosis and Management by Laboratory Methods. 23rd ed. St Louis, MO: Elsevier; 2017:chap 22.