Acquired qualitative platelet disorders; Acquired disorders of platelet function
Acquired platelet function defects are conditions that prevent clotting elements in the blood called platelets from working as they should. The term acquired means these conditions are not present at birth.
Platelet disorders can affect the number of platelets, how well they function, or both. A platelet disorder affects normal blood clotting.
Disorders that can cause problems in platelet function include:
Other causes include:
- Kidney (renal) failure
- Medicines such as aspirin, ibuprofen, other anti-inflammatory drugs, penicillin, phenothiazines, and prednisone (after long-term use)
Symptoms may include any of the following:
Exams and Tests
Tests that may done include:
Treatment is aimed at fixing the cause of the problem:
- Bone marrow disorders are often treated with platelet transfusions or removing platelets from the blood (platelet pheresis).
- Chemotherapy may be used to treat an underlying condition that is causing the problem.
- Platelet function defects caused by kidney failure are treated with dialysis or medicines.
- Platelet problems caused by a certain medicine are treated by stopping the drug.
Most of the time, treating the cause of the problem corrects the defect.
Complications may include:
- Bleeding that does not stop easily
- Anemia (due to excessive bleeding)
When to Contact a Medical Professional
Call your health care provider if:
- You have bleeding and do not know the cause
- Your symptoms get worse
- Your symptoms do not improve after you are treated for an acquired platelet function defect
Using medicines as directed can reduce the risk of drug-related acquired platelet function defects. Treating other disorders may also reduce the risk. Some cases cannot be prevented.
Diz-Kucukkaya R, Lopez JA. Acquired disorders of platelet function. In: Hoffman R, Benz EJ, Silberstein LE, et al, eds. Hematology: Basic Principles and Practice. 7th ed. Philadelphia, PA: Elsevier; 2018:chap 130.
Hall JE. Hemostasis and blood coagulation. In: Hall JE, ed. Guyton and Hall Textbook of Medical Physiology. 13th ed. Philadelphia, PA: Elsevier; 2016:chap 37.
Jobe SM, Di Paola J. Congenital and acquired disorders of platelet function and number. In: Kitchens CS, Kessler CM, Konkle BA, Streiff MB, Garcia DA, eds. Consultative Hemostasis and Thrombosis. 4th ed. Philadelphia, PA: Elsevier; 2019:chap 9.